Thanks for the references, especially to the new Mo et al. 2025 article: Antidepressant use and cognitive decline in patients with dementia: a national cohort study. https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-025-03851-3. They mentioned the very widely used SSRI sertraline (Zoloft) first in their list of drugs their research indicated was associated with the greatest rates of cognitive decline. However, escitalopram (Lexapro), which is also very widely used, was found to be associated with greater rates of cognitive decline.
It is difficult to untangle correlations and the direction of causality. A placebo controlled randomised control trial would be needed to do that, and it would need to run for several years at least.
Good 25-hydroxyvitamin D levels reduce the risk of neurodegeneration (Alzheimer's disease, Parkinson's disease, multiple system atrophy, dementia with Lewy bodies etc.): https:// vitamindstopscovid.info/00-evi/#3.3.
No matter what foods we eat, what medical treatments we accept, what lifestyle choices we make and what genes we inherit, we can only be fully healthy if we have at least the 50 ng/mL 125 nmol/L (1 part in 20,000,000 by mass) circulating 25-hydroxyvitamin D which our immune system needs to function properly.
This cannot be attained by food alone. If we are to attain it, the choice is between year-round high-level UV-B skin exposure and vitamin D3 supplementation, or perhaps enough of each to add up to the vitamin D3 supply we need. Vitamin D3 cholecalciferol, ingested or produced from 7-dehydrocholesterol in the skin when UV-B light breaks one of its carbon rings, is hydroxylated mainly in the liver to 25-hydroxyvitamin D calcifediol (AKA "calcidiol"). About 1/4 of ingested vitamin D3 goes into circulation as the 25-hydroxyvitamin D which the kidneys and many types of immune cell need. Neither of these two compounds act as hormones.
Please see the research cited and discussed at: https:// vitamindstopscovid.info/00-evi/. This begins with recommendations from New Jersey based Professor of Medicine, Sunil Wimalawansa on the average daily supplemental intake quantities of vitamin D3 which will attain least 50 ng/mL circulating 25-hydroxyvitamin D, over several months, without the need for blood tests or medical monitoring.
For 70 kg (154 lb) body weight without obesity, this is about 0.125 milligrams (125 micrograms 5000 IU) a day. This takes several months to attain the desired > 50 ng/mL circulating 25-hydroxyvitamin D. This is 8 or more times what most governments recommend. "5000 IU" a day sounds like a lot, but it is a gram every 22 years - and pharma-grade vitamin D costs about USD$2.50 a gram ex-factory.
Depressed people taking SSRIs are more likely to be killed by Methylene Blue.
Its metabolite Azure Blue is much more lethal accounting for delayed reactions.
https://geoffpain.substack.com/p/methylene-blue-deaths-understood
Thanks Geoff! I've been quite taken aback by this sudden promotion of methylene blue in the 'wellness' industry. What do you make of it?
Hello Robyn, a popular term in US for people promoting high risk "cures" is Grifters.
Their Snake Oils and Pills don't even carry the country of origin or mandatory warnings, for example products containing Phenyalanine.
Caveat emptor!
Brilliant. Couldn't agree more. The harm from anti-depressants is never ending.
Never ending, all right. I think we'll still be uncovering more harms inflicted by these drugs in 50 years.
I agree. Though there may be no one left by then who hasn't taken them or wasn't exposed to them in utero. Sigh.
Thanks for the references, especially to the new Mo et al. 2025 article: Antidepressant use and cognitive decline in patients with dementia: a national cohort study. https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-025-03851-3. They mentioned the very widely used SSRI sertraline (Zoloft) first in their list of drugs their research indicated was associated with the greatest rates of cognitive decline. However, escitalopram (Lexapro), which is also very widely used, was found to be associated with greater rates of cognitive decline.
It is difficult to untangle correlations and the direction of causality. A placebo controlled randomised control trial would be needed to do that, and it would need to run for several years at least.
Good 25-hydroxyvitamin D levels reduce the risk of neurodegeneration (Alzheimer's disease, Parkinson's disease, multiple system atrophy, dementia with Lewy bodies etc.): https:// vitamindstopscovid.info/00-evi/#3.3.
No matter what foods we eat, what medical treatments we accept, what lifestyle choices we make and what genes we inherit, we can only be fully healthy if we have at least the 50 ng/mL 125 nmol/L (1 part in 20,000,000 by mass) circulating 25-hydroxyvitamin D which our immune system needs to function properly.
This cannot be attained by food alone. If we are to attain it, the choice is between year-round high-level UV-B skin exposure and vitamin D3 supplementation, or perhaps enough of each to add up to the vitamin D3 supply we need. Vitamin D3 cholecalciferol, ingested or produced from 7-dehydrocholesterol in the skin when UV-B light breaks one of its carbon rings, is hydroxylated mainly in the liver to 25-hydroxyvitamin D calcifediol (AKA "calcidiol"). About 1/4 of ingested vitamin D3 goes into circulation as the 25-hydroxyvitamin D which the kidneys and many types of immune cell need. Neither of these two compounds act as hormones.
Please see the research cited and discussed at: https:// vitamindstopscovid.info/00-evi/. This begins with recommendations from New Jersey based Professor of Medicine, Sunil Wimalawansa on the average daily supplemental intake quantities of vitamin D3 which will attain least 50 ng/mL circulating 25-hydroxyvitamin D, over several months, without the need for blood tests or medical monitoring.
For 70 kg (154 lb) body weight without obesity, this is about 0.125 milligrams (125 micrograms 5000 IU) a day. This takes several months to attain the desired > 50 ng/mL circulating 25-hydroxyvitamin D. This is 8 or more times what most governments recommend. "5000 IU" a day sounds like a lot, but it is a gram every 22 years - and pharma-grade vitamin D costs about USD$2.50 a gram ex-factory.