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Do you think your MIL had a fibre poor diet ? Do you think these neuro toxins are a threshold thing such that once a certain threshold is reached / accumulated, that cognitive decline starts to accelerate? And are there thinkings that can flush these toxins too ? Whilst I agree you re. Plant based diet, i have to contrast it with Jordan P’s experience, which is totally carnivorous. I guess everyone is different. Food for though (no pun intended)

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My MIL's fibre intake was probably a bit higher than average as she had some clues about diet, but still way below the species optimum. Also she suffered from vascular dementia rather than Alzheimer's, and the process of neurodegeneration in her case was somewhat different to that of Alzheimer's.

I have no doubt that there's a threshold effect with neurotoxins as with other toxins; the body can cope with a certain level of damage, but once that reserve is exhausted, damage becomes manifest. Not sure what you mean by 'thinkings that can flush these toxins' - could you clarify?

One factor that's incredibly important for flushing out neurotoxins is adequate sleep, without which the glymphatic system (the central nervous system's 'version' of the lymphatic system) begins to malfunction quite quickly.

I don't dispute Jordan Peterson's personal experience of subjectively feeling better on a carnivore diet, but such a diet is utterly antithetical to the evolutionary diet of humans, as well as evidence gathered from healthy groups of humans (e.g. extant gatherer hunter groups, plus participants in the American and British Gut Projects). The study of coproliths (fossilised faeces) indicates that ancestral humans ate upward of 100 g of fibre per day. Eating a zero fibre diet for an extended period of time is asking for trouble.

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Thanks. For some reason, my spelling on substack is atrocious (early onset of AD ?). I think I meant to say something like "substances" e.g. apparently water with high levels of silicic acid can help flush out aluminium. I'm interested in this sort of stuff.

As as an aside, I will be heading north again, passing through on 25/06 though doubt I will have time to stop.

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Chris Exley's work demonstrating the effect of silicon-rich water on reducing aluminium burden is very encouraging. It's such a low-cost intervention!!! The only concern I have is that most of the silicon-rich drinking waters are packaged in plastic which has its own problems.

If you do have time to catch up on 25 June, let me know.

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